Mitochondria Release Leads from Human Lung Transplant Recipients Promotes Primary Graft Dysfunction
نویسندگان
چکیده
منابع مشابه
Primary airway epithelial cell culture from lung transplant recipients.
Long-term survival in lung transplantation is limited by the development of obliterative bronchiolitis, a condition characterised by inflammation, epithelial injury, fibroproliferation and obliteration of bronchioles leading to airflow obstruction. To investigate the role of the bronchial epithelium in the pathogenesis of obliterative bronchiolitis the current study aimed to establish primary b...
متن کاملThe Role of Donor Chronic Alcohol Abuse in the Development of Primary Graft Dysfunction in Lung Transplant Recipients
Primary graft dysfunction (PGD) following lung transplantation is clinically similar to the acute respiratory distress syndrome. Because alcohol abuse independently increases the incidence of acute respiratory distress syndrome in at-risk individuals, we hypothesized that donor alcohol use is correlated with an increased risk of PGD. As a pilot study, we collected alcohol use histories using a ...
متن کاملPrimary Graft Dysfunction After Lung Transplantation.
Primary graft dysfunction is a form of acute injury after lung transplantation that is associated with significant short- and long-term morbidity and mortality. Multiple mechanisms contribute to the pathogenesis of primary graft dysfunction, including ischemia reperfusion injury, epithelial cell death, endothelial cell dysfunction, innate immune activation, oxidative stress, and release of infl...
متن کاملSingle-lung Transplant Recipients
• BACKGROUND Many benefits and adverse effects of positioning are related to changes in ventilation and perfusion. A number of unique factors related to the allograft make the effects of positioning difficult to determine in single-lung transplant recipients. • OBJECTIVES To determine the effect of 3 body positions (supine, lateral with allograft lung down, and lateral with native lung down) on...
متن کاملAnti-type V collagen humoral immunity in lung transplant primary graft dysfunction.
Primary graft dysfunction (PGD) is a major complication following lung transplantation. We reported that anti-type V collagen (col(V)) T cell immunity was strongly associated with PGD. However, the role of preformed anti-col(V) Abs and their potential target in PGD are unknown. Col(V) immune serum, purified IgG or B cells from col(V) immune rats were transferred to WKY rat lung isograft recipie...
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ژورنال
عنوان ژورنال: The Journal of Heart and Lung Transplantation
سال: 2016
ISSN: 1053-2498
DOI: 10.1016/j.healun.2016.01.434